微反应器技术及其研究进展Microreactor Technology and Its Research Progress
吴迪;高朋召;
摘要(Abstract):
微反应器技术因具有能耗低、效率高、自动化程度高、反应的可靠性和安全性高、过程可控性以及产物的选择性和环保等方面均显示出独特的优势,成为当今化工领域的研究热点之一。本文介绍了微反应器的基本概念、分类、性能以及在精细化工、纳米颗粒和多级结构材料制备等方面的应用,总结了微反应器的现存问题,并对其下一步研究方向做出了展望。
关键词(KeyWords): 微反应器;性能;混合机理;应用
基金项目(Foundation):
作者(Authors): 吴迪;高朋召;
DOI: 10.13958/j.cnki.ztcg.2018.05.005
参考文献(References):
- [1]FANELLI F,PARISI G,DEGENNARO L,et al.Contribution of microreactor technology and flow chemistry to the development of green and sustainable synthesis[J].Beilstein Journal of Organic Chemistry,2017,13(1):520-542.
- [2]FENG Z V,EDELMAN K R,SWANSON B P.Studentfabricated microfluidic devices as flow reactors for organic and inorganic synthesis[J].Journal of Chemical Education,2015,92(4):723-727.
- [3]GEYER K,CODEE J D,SEEBERGER P H.Microreactors as tools for synthetic chemists-the chemists'round-bottomed flask of the 21st century[J].Chemistry:A European Journal,2010,12(33):8434-8442.
- [4]MATLOSZ M,EHRFELD W,BASELT J P.Micro Reaction Technology,2002,3(3):237-238.
- [5]KISS A A.Process Intensification:Industrial Applications[C]//Process Intensification in Chemical Engineering.Springer International Publishing,2016.
- [6]JENSEN K F.Flow chemistry:Microreaction technology comes of age[J].Aiche Journal,2017,63(3):858-869.
- [7]ZHANG X,WILES C,PAINTER S L,et al.Microreactors as tools for chemical research[J].Chimica Oggi,2006,24(2):43-45.
- [8]GAMBHIRE S,PATEL N,GAMBHIRE G,et al.A review on different micromixers and its micromixing within microchannel.Int.J.Curr.Eng.Technol,2016,4:409-413.
- [9]Farshchian B,Amirsadeghi A,Choi J,et al.3D nanomolding and fluid mixing in micromixers with micro-patterned microchannel walls[J].Nano Converg,2017,4:4-13.
- [10]WARD K,FAN Z H.Mixing in microfluidic devices and enhancement methods[J].Micromech.Microeng,2016,25:1-17.
- [11]刘伟.微通道反应器的构建及其应用[D].济南:山东大学,2016.
- [12]YAO Xingjun,ZHANG Yan,DU Lingyun,et al.Review of the applications of microreactors[J].Renewable and Sustainable Energy Reviews,2015,47:519-539.
- [13]SURYAWANSHI P L,GUMFEKAR S P,BHANVASE B A,et al.A review on microreactors:reactor fabrication,design,and cutting-edge applications[J].Chemical Engineering Science,2018:431-448.
- [14]PHILLIPS T W,LIGNOS I G,MACEICZYK R M,et al.Nanocrystal synthesis in microfluidic reactors:where next?[J].Lab Chip,2014,14:3172-3180.
- [15]WATTS P,HASWELL S J.The application of micro reactors for organic synthesis[J].Cheminform,2005,34(3):235-246.
- [16]DIETRICH T R,FREITAG A,SCHOLZ R.Production and characteristics of microreactors made from glass[J].Chemical Engineering&Technology,2010,28(4):477-483.
- [17]FITZPATRICK D E,BATTILOCCHIO C,LEY S V.A novel internet-based reaction monitoring,control and autonomous self-optimization platform for chemical synthesis[J].Organic Process Research&Development,2016,20(2):386-394.
- [18]托马斯·沃思.微反应器在有机合成及催化中的应用[M].赵东波译.北京:化学工业出版社,2012:16-18.
- [19]NAGAKI A,TAKABAYASHI N,TOMIDA Y,et al.Selective monolithiation of dibromobiaryls using microflow systems[J].Organic Letters,2008,10(18):3937-40.
- [20]BRANDNER J J.Metallic,Steel,Ceramic and Plastic Microreactors[C]//Micro Process Engineering:A Comprehensive Handbook,Volume 1,2&3.Wiley-VCH Verlag GmbH&Co.KGaA,2013:25-43.
- [21]MALETSANZ L,SUSANNE F.Continuous flow synthesis:Apharma perspective[J].Journal of Medicinal Chemistry,2012,55(9):4062-4098.
- [22]FOUILLET Y,PARENT C,GROPPLERO G,et al.Stretchable material for microfluidic applications[J].Proceedings,2017,1(4):501-504.
- [23]HALLDORSSON S,LUCUMI E,GóMEZ-SJ?BERG R,et al.Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices[J].Biosensors&Bioelectronics,2015,63:218-231.
- [24]AMII H,NAGAKI A,YOSHIDA J.Flow microreactor synthesis in organo-fluorine chemistry[J].Beilstein Journal of Organic Chemistry,2014,45(29):2793-2802.
- [25]MAE K.Advanced chemical processing using microspace[J].Chem Eng Sci,2007,62(18):4842-4851.
- [26]陈光文,赵玉潮,乐军,等.微化工过程中的传递现象[J].化工学报,2013,64(1):63-75.
- [27]刘武.Maxwell-Stefan理论用于液相多组分体系中扩散系数的预测[D].北京:北京化工大学,2011.
- [28]JOVANOVI?J,REBROV E V,NIJHUIS T A,et al.Liquidliquid flow in a capillary microreactor:hydrodynamic flow patterns and extraction performance[J].Ind Eng Chem Res,2012,51(2):1020-1031.
- [29]LIN X Y,YAN S,ZHOU,B Y,et al.Highly Efficient synthesis of polyvinyl butyral(PVB)using a membrane dispersion microreactor system and recycling reaction technology[J].Green Chem,2017,19(9):2155-2163.
- [30]XIE P,WANG K,LUO G.Calcium stearate as acid scavenger for synthesizing bromobutyl rubber at high concentration in a microreactor system[J].Industrial&Engineering Chemistry Research,2018,57(11):3898-3907.
- [31]卜橹轩,谢天明,邓秋林,等.微结构反应器中连续快速制备多种萘系磺酸[J].南京工业大学学报(自然科学版),2012,34(3):61-65.
- [32]WAKAMI H,YOSHIDA J.Grignard exchange reaction using a microflow system:From bench to pilot plant[J].Organic Process Research&Development,2005,9(6):787-791.
- [33]PORTA R,BENAGLIA M,PUGLISI A.Flow chemistry:Recent developments in the synthesis of pharmaceutical products[J].Org Process Res Dev.,2016,20:2-25.
- [34]HESSEL V,DANA K,KOCKMANN N,et al.Novel Process windows for enabling,accelerating,and uplifting flow chemistry[J].Chemsuschem,2013,6(5):746-789.
- [35]YOSHIDA J I,KIM H,NAGAKI A.Green and sustainable chemical synthesis using flow microreactors[J].Chemsuschem,2011,4(3):331-340.
- [36]ATOBE M,TATENO H,MATSUMURA Y.Applications of flow microreactors in electrosynthetic processes[J].Chemical Reviews,2018,118:4541-4572.
- [37]GUTMANN B,CANTILLO D,KAPPE C O.Continuousflow technology:A tool for the safe manufacturing of active pharmaceutical ingredients[J].Angew Chem Int Ed Engl,2015,46(30):6688-6728.
- [38]NAVARRO-BRULL F J,POVEDA P,RUIZ-FEMENIA R,et al.Guidelines for the design of efficient sono-microreactors[J].Green Processing and Synthesis,2014,3(5):311-320.
- [39]周勇敏.材料工程基础[M].北京:化学工业出版社,2011:41-53.
- [40]王瑞金.微通道中流体扩散和混合机理及其微混合器的研究[D].杭州:浙江大学,2005.
- [41]YANG X,LIN Y.Effect of baffle structure on fluid flow and mixing in the micromixer[J].Journal of Shanghai Institute of Technology,2016,16(4):338-343.
- [42]ZHAO S,DONG Z,YAO C,et al.Liquid-liquid two phase flow in ultrasonic microreactors:Cavitation,emulsification,and mass transfer enhancement[J].Aiche Journal,2018,64(4):1412-1423.
- [43]Hartman R L,McMullen J P,Jensen K F.Deciding Whether To Go with the Flow:Evaluating the Merits of Flow reactors for synthesis[J].Angew Chem Int Edit,2011,50:7502-7519.
- [44]PEREZ F,MUKOTEKWA T,MILLER A,et al.Preparation and control of the size distribution of zirconia nanoparticles in a concentric-axle dual-pipe microreactor[J].Chemical Engineering&Technology,2013,36(6):1027-1032.
- [45]周峰,刘宏臣,王克军,等.连续流微反应器中简单咪唑的制备[J].化工学报,2018(6):2481-2487.
- [46]AGHEL B,MOHADESI M,SAHRAEI S,et al.New heterogeneous process for continuous biodiesel production in microreactors[J].Canadian Journal of Chemical Engineering,2016,95(7):1280.
- [47]MORADI G,MOHADESI M,HOSSEINI S,et al.DM water plant sedimentation as a cheap and waste source of catalyst for biodiesel production[J].International Journal of Chemical Reactor Engineering,2016,14(1):113-124.
- [48]ZHAO C X,HE L,QIAO S Z,et al.Nanoparticle synthesis in microreactors[J].Chemical Engineering Science,2011,66(7):1463-1479.
- [49]WANG Qi’an,WANG Jiexin,LI Min,et al.Large-scale preparation of barium sulphate nanoparticles in a highthroughput tube-in-tube microchannel reactor[J].Chemical Engineering Journal,2009,149:473-478.
- [50]CHESTER A W,DEROUANE E G.Zeolite characterization and catalysis[C]//Zeolite Characterization and Catalysis.Springer,2009:241-50.
- [51]KOOHSARYAN E,ANBIA M.Nanosized and hierarchical zeolites:A short review[J].Chinese Journal of Catalysis,2016,37(4):447-467.
- [52]CUNDY C S,COX P A.The hydrothermal synthesis of zeolites:History and development from the earliest days to the present time[J].Chemical Reviews,2003,103(3):663-702.
- [53]郭松,尹苏娜,潘宜昌,等.微流体技术制备多级结构材料的研究进展[J].中国科学:化学,2015,45(1):24-33.
- [54]YU Liang,PAN Yichang,WANG Chongqing,et al.Atwo-phase segmented microfluidic technique for one-step continuous versatile preparation of zeolites[J].Chemical Engineering Journal,2013,219:78-85.
- [55]ZHENG Z,WANG Y,ZHAO W,et al.Adsorptive removal of uranyl ions in aqueous solution using hydrothermal carbon spheres functionalized with 4-aminoacetophenone oxime group[J].Journal of Radioanalytical&Nuclear Chemistry,2017,312(2):187-198.
- [56]WANG G,PENG H,QIAO X,et al.Biomass-derived porous heteroatom-doped carbon spheres as a high-performance catalyst for the oxygen reduction reaction[J].International Journal of Hydrogen Energy,2016,41(32):14101-14110.
- [57]WANG J,LU Y,ZHANG N,et al.Ultrasmall SnS nanoparticles embedded in carbon spheres:A high-performance anode material for sodium ion batteries[J].Rsc Advances,2016,6(98):95805-95811.
- [58]JU M,ZENG C,WANG C,et al.Preparation of ultrafine carbon spheres by controlled polymerization of furfuryl alcohol in microdroplets[J].Ind Eng Chem Res,2014,53:3084-3090.
- [59]FLOWERS B S,HARTMAN R L.Particle handling techniques in microchemical processes[J].Challenges,2012,3(2):194-211.
- [60]TONOMURA O,KANO J I,KANO M,et al.Process monitoring of tubular microreactors using particle filter[J].IFAC Proceedings,2010,43(5):427-432.
- [61]TANAKA Y,TONOMURA O,ISOZAKI K,et al.Detection and diagnosis of blockage in parallelized microreactors[J].Chemical Engineering Journal,2011,167(2-3):483-489.
- [62]曹晨熙,张辇,储博钊,等.微结构反应器气固相催化过程强化的研究与工业化进展[J].化工学报,2018,69(1):295-308.