杨笑然;吴振宁;吴志炜;王博文;张垠;

• 1:南京工业大学材料科学与工程学院

摘要(Abstract)：

生物活性玻璃已被广泛认为是有效的骨头和牙齿的修复材料。正是因为生物玻璃具有生物活性、生物相容性、可降解性和一定的机械强度等,使其拥有较高临床应用价值。事实上,已经证实了生物玻璃的离子溶解产物(如:Si⁽⁴⁺⁾、Ca(4+)、Ca⁽²⁺⁾、P(2+)、P⁽⁵⁺⁾、B(5+)、B⁽³⁺⁾)能够有效诱导和刺激成骨细胞增殖与分化,新血管的再生,甚至发挥抗菌抗炎的功效。因此适量的调整生物玻璃的组成并添加一些特定的离子,能有效提高生物玻璃的生物性能、并能拓宽其应用领域。本综述的目的是介绍几种离子(如:Ga(3+))能够有效诱导和刺激成骨细胞增殖与分化,新血管的再生,甚至发挥抗菌抗炎的功效。因此适量的调整生物玻璃的组成并添加一些特定的离子,能有效提高生物玻璃的生物性能、并能拓宽其应用领域。本综述的目的是介绍几种离子(如:Ga⁽³⁺⁾、Cu(3+)、Cu⁽²⁺⁾、Zn(2+)、Zn⁽²⁺⁾、Ag(2+)、Ag⁺、Mg+、Mg⁽²⁺⁾)作为掺杂剂对生物玻璃性能的影响。

关键词(KeyWords)： 有序介孔生物玻璃;掺杂离子;生物性能

Abstract:

Keywords:

基金项目(Foundation): 江苏省大学生创新创业训练计划成果(201810291017Z);; 江苏高校优势学科建设工程资助项目;; 江苏省先进无机功能复合材料协同创新中心项目

作者(Authors): 杨笑然;吴振宁;吴志炜;王博文;张垠;

DOI: 10.13958/j.cnki.ztcg.2018.04.004

参考文献(References)：

• [1]HENCH L L,XYNOS I D,POLAK J M.Bioactive glasses for in situ tissue regeneration[J].Journal of Biomaterials Science Polymer Edition,2004,15(4):543-562.
• [2]HENCH L L.Bioceramics:From Concept to Clinic[J].Journal of the American Ceramic Society,1991,74(7):1487-1510.
• [3]YAN X X,DENG H X,HUANG X H,et al.Mesoporous bioactive glasses.I.Synthesis and structural characterization[J].Journal of Non-Crystalline Solids,2005,351(40-42):3209-3217.
• [4]DURAND L A H,GONGORA A,LOPEZ J M P,et al.In vitro endothelial cell response to ionic dissolution products from boron-doped bioactive glass in the Si O2-Ca O-P2O5-Na2Osystem[J].Journal of Materials Chemistry B,2016,2(43):7620-7630.
• [5]DZONDO-GADET M,MAYAP-NZIETCHUENG R,HESS K,et al.Action of boron at the molecular level[J].Biological Trace Element Research,2002,85(1):23-33.
• [6]LANSDOWN A B.Metallothioneins:Potential therapeutic aids for wound healing in the skin[J].Wound Repair&Regeneration,2002,10(3):130.
• [7]REFFITT D M,OGSTON N,JUGDAOHSINGH R,et al.Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro[J].International Review of Hydrobiology,2003,32(2):127-135.
• [8]POURSHAHRESTANI S,KADRI N,ZEIMARAN E,et al.Comparative efficacy of hemorrhage control of a novel mesoporous bioactive glass versus two commercial hemostats[J].Biomedical Materials,2017,13(2).
• [9]HENCH L L,SPLINTER R J,ALLEN W C,et al.Bonding mechanisms at the interface of ceramic prosthetic materials[J].Journal of Biomedical Materials Research Part A,1971,5(6):117-141.
• [10]LI Y,LIU Y Z,LONG T,et al.Mesoporous bioactive glass as a drug delivery system:fabrication,bactericidal properties and biocompatibility[J].J Mater Sci Mater Med,2013,24(8):1951-1961.
• [11]许云强,周国伟,李艳敬,等.有序介孔材料作为药物控释载体的研究进展[J].化工进展,2010,29(4):677-682.
• [12]XIA W,CHANG J.Well-ordered mesoporous bioactive glasses(MBG):A promising bioactive drug delivery system[J].Journal of Controlled Release,2006,110(3):522-530.
• [13]FENG X X,JIANG Chang.Synthesis of a well-ordered mesoporous 58S bioactive glass by a simple method[J].International Journal of Applied Ceramic Technology,2011,8(3):547-552.
• [14]WILLIAMS D F.Definitions in biomaterials[C]//Proceedings of a Consensus Conference of the European Society for Biomaterials,Chester,England,March 3-5,1986.European Society for Biomaterials,Elsevier,1987.
• [15]HENCH L L,GREENSPAN D.Interactions between bioactive glass and collagen:A review and new perspectives[J].Journal of the Australian Ceramic Society,2013,49(2):1-40.
• [16]黄晓晖,严晓霞,韩路,等.介孔生物活性玻璃材料在模拟体液中的用量对考察其体外生物活性的影响[J].化学学报,2006,64(9):851-857.
• [17]钟吉品,Hench.生物玻璃的研究与发展[J].无机材料学报,1995(2):129-138.
• [18]赵莉,林开利,常江.生物活性陶瓷材料表面碳酸羟基磷灰石形成及其微观结构的研究[J].无机材料学报,2003,18(6):1280-1286.
• [19]HENCH L L.The story of Bioglass?[J].Journal of Materials Science Materials in Medicine,2006,17(11):967-978.
• [20]李佩国,张继东.不同浓度钙离子对凝血I,II及XIII因子的作用[J].中国兽医学报,1997(1):75-77.
• [21]POURSHAHRESTANI S,ZEIMARAN E,KADRI N A,et al.Gallium-containing mesoporous bioactive glass with potent hemostatic activity and antibacterial efficacy[J].Journal of Materials Chemistry B,2015,4(1):71-86.
• [22]MAENO S,NIKI Y H,MORIOKA H,et al.The effect of calcium ion concentration on osteoblast viability,proliferation and differentiation in monolayer and 3D culture[J].Biomaterials,2005,26(23):4847.
• [23]李享德,吴钊英,邓玉虎,等.无机介孔钙硅基止血材料的制备及性能研究[J].化学世界,2012(s1):13-17.
• [24]JULIEN M,KHOSHNIAT S,LACREUSETTE A,et al.Phosphate-dependent regulation of MGP in osteoblasts:role of ERK1/2 and Fra-1[J].Journal of Bone&Mineral Research,2009,24(11):1856-1868.
• [25]苏明明.抗肿瘤新药Ga(III)-EDTMP的制备、表征和药效学研究[D].天津大学,2005.
• [26]马超.无机镓化合物抗菌性能研究[D].西南交通大学,2015.
• [27]李青仁,王月梅.微量元素铜与人体健康[J].微量元素与健康研究,2007,24(3):61-63.
• [28]CACCIOTTI I.Bivalent cationic ions doped bioactive glasses:the influence of magnesium,zinc,strontium and copper on the physical and biological properties[J].Journal of Materials Science,2017,52(15):8812-8831.
• [29]GOH Y F,ALSHEMARY A Z,AKRAM M,et al.Bioactive glass:An in-vitro comparative study of doping with nanoscale copper and silver particles[J].International Journal of Applied Glass Science,2014,5(3):255-266.
• [30]WANG X,FANG C,LIU J,et al.Biocomposites of coppercontaining mesoporous bioactive glass and nanofibrillated cellulose:Biocompatibility and angiogenic promotion in chronic wound healing application[J].Acta Biomaterialia,2016,46:286-298.
• [31]BORKOW G,GABBAY J,ZATCOFF R.Could chronic wounds not heal due to too low local copper levels?[J].Medical Hypotheses,2008,70(3):610-613.
• [32]LI Xia,WANG Xiupeng,HE Dannong,et al.Synthesis and characterization of mesoporous Ca O-MO-Si O2-P2O5(M=Mg,Zn,Cu)bioactive glasses/composites[J].Journal of Materials Chemistry,2008,18(34):4103-4109.
• [33]LI J,ZHAI D,LV F,et al.Preparation of copper-containing bioactive glass/eggshell membrane nanocomposites for improving angiogenesis,antibacterial activity and wound healing[J].Acta Biomaterialia,2016,36:254-266.
• [34]GERARD C,BORDELEAU L J,BARRALET J,et al.The stimulation of angiogenesis and collagen deposition by copper[J].Biomaterials,2010,31(5):824-831.
• [35]RATH S N,BRANDL A,HILLER D,et al.Bioactive copperdoped glass scaffolds can stimulate endothelial cells in coculture in combination with mesenchymal stem cells[J].Plos One,2014,9(12):e113319.
• [36]陈丽,韩太真.镁的生理调节[J].国外医学医学地理分册,2003,24(3):110-112.
• [37]黄琴,梁惠,杜凤沛.镁的生理与临床应用[J].微量元素与健康研究,2005,22(2):61-63.
• [38]DIETRICH E,OUDADESSE H,LUCASGIROT A,et al.In vitro bioactivity of melt-derived glass 46S6 doped with magnesium[J].Journal of Biomedical Materials Research Part A,2010,88A(4):1087-1096.
• [39]杜瑞林,常江.含Zn、Mg生物玻璃的制备及性能研究[J].无机材料学报,2004,19(6):1353-1358.
• [40]周毅峰,吴永尧,唐巧玉,等.锌的生物学功能[J].氨基酸和生物资源,2004,26(2):11-15.
• [41]LANG C,MURGIA C,LEONG M,et al.Anti-inflammatory effects of zinc and alterations in zinc transporter m RNA in mouse models of allergic inflammation[J].Am J Physiol Lung Cell Mol Physiol,2007,292(2):L577.
• [42]ANAND V,SINGH K J,KAUR K.Evaluation of zinc and magnesium doped 45S5 mesoporous bioactive glass system for the growth of hydroxyl apatite layer[J].Journal of NonCrystalline Solids,2014,406(406):88-94.
• [43]AINA V,MALAVASI G,FIORIO P A,et al.Zinc-containing bioactive glasses:Surface reactivity and behaviour towards endothelial cells[J].Acta Biomaterialia,2009,5(4):1211-1222.
• [44]BALAMURUGAN A,BALOSSIER G,KANNAN S,et al.Development and in vitro characterization of sol-gel derived Ca O-P2O5-Si O2-Zn O bioglass[J].Acta Biomaterialia,2007,3(2):255-262.
• [45]DU R L,CHANG J,NI S Y,et al.Characterization and in vitro bioactivity of zinc-containing bioactive glass and glassceramics[J].Journal of Biomaterials Applications,2006,20(4):341-360.
• [46]HOPPE A,GüLDAL N S,BOCCACCINI A R.A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics[J].Biomaterials,2011,32(11):2757-74.
• [47]AUGUSTINE R,DOMINIC E,REJU I,et al.Investigation of angiogenesis and its mechanism using zinc oxide nanoparticleloaded electrospun tissue engineering scaffolds[J].Rsc Advances,2014,4(93):51528-51536.
• [48]HU G,XIAO L,TONG P,et al.Antibacterial hemostatic dressings with nanoporous bioglass containing silver[J].International Journal of Nanomedicine,2012,7(default):2613-2620.
• [49]PRATTEN J,NAZHAT S N,BLAKER J J,et al.In vitro attachment of staphylococcus epidermidis to surgical sutures with and without Ag-containing bioactive glass coating[J].Journal of Biomaterials Applications,2004,19(1):47.
• [50]CHALOUPKA K,MALAM Y,SEIFALIAN A M.Nanosilver as a new generation of nanoproduct in biomedical applications[J].Trends in Biotechnology,2010,28(11):580-588.
• [51]NADWORNY P L,WANG J,TREDGET E E,et al.Antiinflammatory activity of nanocrystalline silver in a porcine contact dermatitis model[J].Nanomedicine Nanotechnology Biology&Medicine,2008,4(3):241.